Preferred Label : Fluorine F 18 5-Fluoro-2-deoxycytidine;
NCIt synonyms : [F-18]-FdCyd; [F-18]-5-fluoro-2'-deoxycytidine;
NCIt definition : A radioconjugate composed of a fluorinated pyrimidine analog, linked to the radioisotope
fluorine F 18 with potential imaging activity using positron emission tomography/computed
tomography (PET/CT). Upon administration of fluorine F 18 5-fluoro-2-deoxycytidine
([F-18]-FdCyd), the FdCyd moiety is phosphorylated by deoxycytidine kinase to 5-fluoro-2'-deoxycytidylate
(FdCMP) and deaminated by deoxycytidylate (dCMP) deaminase, an enzyme overexpressed
by tumor cells, to 5-fluoro-2-deoxyuridine monophosphate (FdUMP). Eventually, FdUMP
is metabolized to the triphosphate forms 5-fluoro-2'-deoxycytidine-triphosphate (FdCTP)
and fluorodeoxyuridine triphosphate (FdUTP). FdCTP and FdUTP inhibit DNA methyltransferase
(DNMT) and DNA methylation, and induce DNA strand breaks, respectively. FdCyd is coadministered
with tetrahydrouridine (THU), an inhibitor of cytidine/deoxycytidine deaminase, which
prevents FdCyd breakdown and increases its efficacy. The fluorine F 18 moiety can
be imaged upon PET/CT, thereby allowing for the evaluation of the biodistribution
of FdCyd and its uptake by tumor cells.;
NCI Metathesaurus CUI : CL454074;
Origin ID : C111682;
UMLS CUI : C3826849;
Semantic type(s)
- concept_is_in_subset
