Preferred Label : Carbon C 14 Oxaliplatin;
NCIt synonyms : [14C] Oxaliplatin;
NCIt definition : A radioconjugate composed of the platinum agent oxaliplatin labeled with the isotope
carbon C 14, that can be used to predict the response to oxaliplatin therapy using
accelerator mass spectrometry (AMS). Upon intravenous administration of a microdose
of carbon C 14 oxaliplatin, the oxaliplatin moiety covalently links to DNA and forms
mono- and di-DNA adducts. The platinum-DNA adduct formation can be measured through
quantification of C14-labeled drug-DNA adducts by using AMS. By measuring the microdose-induced
DNA damage, the response to oxaliplatin-based chemotherapy can be assessed and predicted.
Measurements that indicate either low drug-DNA adduct formation or increased DNA repair
(C14 removal from DNA) are correlated with increased resistance to platinum-based
chemotherapeutics.;
NCI Metathesaurus CUI : CL453980;
Origin ID : C111572;
UMLS CUI : C3831201;
Semantic type(s)
- concept_is_in_subset
