Preferred Label : Spanlecortemlocel;
NCIt synonyms : Expanded Umbilical Cord Blood Product HSC835; Allogeneic UCB-derived HSPCs MGTA 456; Allogeneic Umbilical Cord Blood-derived Hematopoietic Stem and Progenitor Cells MGTA-456;
NCIt definition : A preparation of allogeneic umbilical cord blood (UCB)-derived hematopoietic stem
and progenitor cells (HSPCs) expanded in culture with the stimulatory cytokines stem
cell factor (SCF; Kit ligand; mast cell growth factor; MGF), FMS-like tyrosine kinase
3 ligand (Flt3L), interleukin 6 (IL-6), and thrombopoietin, in the presence of an
aryl hydrocarbon receptor (AHR) antagonist LHD221 (StemRegenin-1; SR-1), with potential
to improve hematopoietic recovery following myeloablative conditioning. Upon administration
of Spanlecortemlocel, these cells increase and restore the number of HSPCs, which
may prevent or decrease the risk of infection and other complications of chemotherapy-induced
neutropenia (CIN) or cord blood transplantation. LHD221, an AHR antagonist facilitates
the expansion of CD34-positive hematopoietic progenitors and impedes HSPC differentiation
during cytokine-driven expansion in culture.;
UNII : D8O38M043D;
Molecule name : MGTA 456; HSC 835; MGTA-456; HSC835;
NCI Metathesaurus CUI : CL453979;
Origin ID : C111571;
UMLS CUI : C4743545;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
