Preferred Label : Anti-EGFRvIII CAR-transduced Allogeneic T-lymphocytes;
NCIt synonyms : Anti-EGFRvIII CAR PG13-139-CD8-CD28BBZ- transduced T-lymphocytes;
NCIt definition : Allogeneic human T-lymphocytes transduced with a retroviral vector encoding an anti-epidermal
growth factor receptor (EGFR) variant III (EGFRvIII) mutant chimeric T cell receptor
(chimeric antigen receptor or CAR) gene coupled to the signaling domains from CD8,
CD28, 4-1BB (CD137) and CD3 zeta, with potential immunostimulatory and antineoplastic
activities. Upon administration, the anti-EGFRvIII CAR-transduced allogeneic T lymphocytes
bind to the EGFRvIII antigen on tumor cell surfaces; subsequently, EGFRvIII-expressing
tumor cells may be lysed. EGFRvIII, an in-frame deletion of exons 2-7 in the EGFR
gene, is overexpressed by a variety of cancer cell types and absent in normal, healthy
cells; it plays a key role in tumor cell proliferation, tumor angiogenesis and radio-
and chemoresistance.;
NCI Metathesaurus CUI : CL453973;
Origin ID : C111565;
UMLS CUI : C3831515;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
