" /> Geldanamycin - CISMeF





Preferred Label : Geldanamycin;

NCIt synonyms : Antibiotic U 29135;

NCIt related terms : Antibiotic (U-29,135);

NCIt definition : A benzoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces hygroscopicus. Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be over-expressed or overactive in tumor cells. (NCI04);

UNII : Z3K3VJ16KU;

InChIKey : QTQAWLPCGQOSGP-KSRBKZBZSA-N;

CAS number : 30562-34-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 30562-34-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

NSC code : 212518; 122750;

ChEBI ID : CHEBI:5292;

Codes from synonyms : NSC0122750; 31886;

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15/05/2024


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