" /> Vadastuximab Talirine - CISMeF





Preferred Label : Vadastuximab Talirine;

NCIt definition : An immunoconjugate consisting of a humanized monoclonal antibody that is engineered to contain cysteine residues that are conjugated to the synthetic, DNA cross-linking, pyrrolobenzodiazepine dimer SGD-1882, via the protease-cleavable linker maleimidocaproyl-valine-alanine dipeptide, with potential antineoplastic activity. The monoclonal antibody portion of vadastuximab talirine specifically binds to the cell surface antigen CD33. This causes the internalization of SGN-CD33A, and the release of the cytotoxic moiety SGD-1882. SGD-1882 binds to and crosslinks DNA, which results in both cell cycle arrest and the induction of apoptosis in CD33-expressing tumor cells. CD33, a transmembrane receptor, is expressed on myeloid leukemia cells.;

UNII : T13V17U431;

CAS number : 1436390-64-5;

Molecule name : SGN-CD33A; SGN CD33A;

NCI Metathesaurus CUI : CL453546;

Codes from synonyms : 524;

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01/07/2025


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