NCIt definition : An immunoconjugate consisting of a humanized monoclonal antibody that is engineered
to contain cysteine residues that are conjugated to the synthetic, DNA cross-linking,
pyrrolobenzodiazepine dimer SGD-1882, via the protease-cleavable linker maleimidocaproyl-valine-alanine
dipeptide, with potential antineoplastic activity. The monoclonal antibody portion
of vadastuximab talirine specifically binds to the cell surface antigen CD33. This
causes the internalization of SGN-CD33A, and the release of the cytotoxic moiety SGD-1882.
SGD-1882 binds to and crosslinks DNA, which results in both cell cycle arrest and
the induction of apoptosis in CD33-expressing tumor cells. CD33, a transmembrane receptor,
is expressed on myeloid leukemia cells.;
UNII : T13V17U431;
CAS number : 1436390-64-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1436390-64-5
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