Gallium Nitrate

Preferred Label : Gallium Nitrate;

NCIt synonyms : GaN;

NCIt definition : A hydrated nitrate salt of the group IIIa element gallium with potential use in the treatment of malignancy-associated hypercalcemia. Gallium nitrate localizes preferentially to areas of bone resorption and remodeling and inhibits osteoclast-mediated resorption by enhancing hydroxyapatite crystallization and reduction of bone mineral solubility. This agent also increases calcium and phosphorous deposition into bone and may increase collagen synthesis. (NCI04);

Alternative definition : NCI-GLOSS: A drug that lowers blood calcium. Used as treatment for hypercalcemia (too much calcium in the blood) and for cancer that has spread to the bone (bone metastases).;

UNII : VRA0C6810N;

InChIKey : GOMSPTBXILHTSG-UHFFFAOYSA-N;

CAS number : 135886-70-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 135886-70-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Ganite;

Molecule name : WR-135675;

Chemical formula : Ga.3NO3.9H2O;

NSC code : 15200;

Codes from synonyms : CDR0000045202; NSC0015200;

Details

Origin ID

C1109;

UMLS CUI

C0061008;

Automatic exact mappings (from CISMeF team)
- Giant axonal neuropathy [ORDO Disease]
- Giant axonal neuropathy [ICD-11 More detail]
- Giant axonal neuropathy 1, autosomal recessive [OMIM Phenotype]
- Gigaxonin [OMIM gene]
- poly(dG-dA)n.poly(dC-dT)n [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- Gallium nitrate (substance) [SNOMED CT concept]
- Product containing gallium nitrate (medicinal product) [SNOMED CT concept]
- gallium nitrate [MeSH concept]
- gallium nitrate [MeSH Supplementary Concept]
- gallium trinitrate [Substance BNPC]
Semantic type(s)
- Indicator, Reagent, or Diagnostic Aid [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Gallium nitrate (substance) [SNOMED CT concept]
- Product containing gallium nitrate (medicinal product) [SNOMED CT concept]
- gallium nitrate [MeSH concept]
- gallium nitrate [MeSH Supplementary Concept]
- gallium trinitrate [Substance BNPC]
chemical_or_drug_affects_cell_type_or_tissue
- Osteoclast [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Unknown Cellular or Molecular Mechanism [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Bone Resorption Inhibition [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Filgrastim/Gallium Nitrate/Paclitaxel [NCIt concept]
- Fluorouracil/Gallium Nitrate [NCIt concept]
- Gallium Nitrate/Hydroxyurea [NCIt concept]
- Gallium Nitrate/Ifosfamide/Vinblastine [NCIt concept]
- Gallium Nitrate/Paclitaxel [NCIt concept]

Keyword's position in hierarchy(ies) :

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