" /> Fotemustine - CISMeF





Preferred Label : Fotemustine;

NCIt synonyms : 1-[N-(2-chloroethyl)-N-nitrosoureido]ethylphosphonic acid diethyl ester; [1-[[[(2-chloroethyl)nitrosamino]-carbonyl]amino]ethyl]phosphonic acid diethyl ester; diethyl[1-[3-(2-chloroethyl)-3-nitrosoureido]ethyl]phosphonate;

NCIt definition : A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of brain tumors and metastatic melanoma of the eye. It is a type of nitrosourea.;

UNII : GQ7JL9P5I2;

InChIKey : YAKWPXVTIGTRJH-UHFFFAOYSA-N;

CAS number : 92118-27-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 92118-27-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Muphoran;

Molecule name : S 10036;

Chemical formula : C9H19ClN3O5P;

Codes from synonyms : CDR0000439437; 235;

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12/05/2024


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