Mitoflaxone - CISMeF

Preferred Label : Mitoflaxone;

NCIt synonyms : 4H-1-benzopyran-8-acetic Acid, 4-Oxo-2-phenyl; Flavone-8-Acetic Acid; 2-Phenyl-8-(carboxymethyl)-benzopyran-4-one; FAA;

NCIt related terms : Flavone acetic acid; 4H-1-Benzopyran-8-acetic acid, 4-oxo-2-phenyl-;

NCIt definition : A synthetic flavonoid with vascular targeting properties. Flavone acetic acid exhibits an antiproliferative effect on endothelial cells as a result of a superoxide-dependent mechanism, which induces changes in permeability of the vasculature of the tumor. This agent may stimulate tumor necrosis and promote shunting of blood flow to viable regions of the tumor, increasing their oxygenation and rendering them more susceptible to the antitumor effects of hyperthermia and ionizing radiation. (NCI04);

UNII : X230G6E63B;

InChIKey : TZZNWMJZDWYJAZ-UHFFFAOYSA-N;

CAS number : 87626-55-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 87626-55-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : LM 975;

Chemical formula : C17H12O4;

NSC code : 347512;

Codes from synonyms : NSC0347512;

Details

Origin ID

C1101;

UMLS CUI

C2987522;

Currated CISMeF NLP mapping
- flavone acetic acid [MeSH concept]
- flavone acetic acid [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Flavone Acetic Acid/Interleukin-2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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