NCIt related terms : Flavone acetic acid; 4H-1-Benzopyran-8-acetic acid, 4-oxo-2-phenyl-;
NCIt definition : A synthetic flavonoid with vascular targeting properties. Flavone acetic acid exhibits
an antiproliferative effect on endothelial cells as a result of a superoxide-dependent
mechanism, which induces changes in permeability of the vasculature of the tumor.
This agent may stimulate tumor necrosis and promote shunting of blood flow to viable
regions of the tumor, increasing their oxygenation and rendering them more susceptible
to the antitumor effects of hyperthermia and ionizing radiation. (NCI04);