" /> Fazarabine - CISMeF





Preferred Label : Fazarabine;

NCIt synonyms : 1-Beta-D-arabinofuranosyl-5-azacytosine; 1,3, 5-Triazin-2(1H)-one, 4-Amino-1-beta-D- arabinofuranosyl- (9CI); ara-AC;

NCIt related terms : Kymarabine; 1,3, 5-Triazin-2(1H)-one, 4-amino-1-.beta.-D- arabinofuranosyl- (9CI); 1-.beta.-D-Arabinofuranosyl-5-azacytosine; Ara AC;

NCIt definition : An orally-active pyrimidine analogue of an aza-substituted cytidine in which the ribose moiety is replaced by an arabinose sugar. Similar in action to cytarabine, fazarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; its incorporation into DNA inhibits DNA synthesis, resulting in tumor cell death and tumor necrosis. The presence of deoxycytidine kinase in a tumor is a determinant of tumor sensitivity to this drug. (NCI04);

Alternative definition : NCI-GLOSS: An anticancer drug that is a type of antimetabolite.;

UNII : 5V71D8JOKK;

InChIKey : NMUSYJAQQFHJEW-ARQDHWQXSA-N;

CAS number : 65886-71-7;

Chemical formula : C8H12N4O5;

NSC code : 281272;

Codes from synonyms : NSC0281272; CDR0000045302;

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Keyword's position in hierarchy(ies) : arborescence

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31/05/2025


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