" /> Staphylococcal Enterotoxin B - CISMeF





Preferred Label : Staphylococcal Enterotoxin B;

NCIt synonyms : SEB;

NCIt definition : A bacterial enterotoxin with potential immunostimulatory activity. Staphylococcal enterotoxin B (SEB), a gram positive superantigen produced by Staphylococcus aureus, is a potent stimulator of T-cell activation. SEB binds directly to class II major histocompatibility complex (MHC) molecules and the V beta region of the T-cell receptor (TCR), leading to an amplified T-cell response. In response to SEB, both CD4 and CD8 cells proliferate, secrete cytokines and demonstrate enhanced cytotoxic activity against a broad range of antigens. Co-administration of SEB with interleukin-2 (IL-2) by direct injection into tumor cells, may induce clonal T-cell expansion and potentiate apoptosis of tumor cells, resulting in decreased tumor growth.;

Alternative definition : CDISC: The biotoxin Staphylococcal enterotoxin B.;

CAS number : 39424-53-8;

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28/05/2025


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