Preferred Label : BC-819 Plasmid/Polyethylenimine Complex;
NCIt synonyms : BC-819/PEI; DTA-H19/PEI;
NCIt definition : A plasmid DNA encoding for the A fragment of Diphtheria Toxin (DTA) under the control
of the H19 gene promoter (BC-819 or DTA-H19) and mixed with the transfectant polyethylenimine
(PEI), with potential antineoplastic activity. Upon administration, the PEI moiety
enhances the entry of the agent into rapidly dividing cells. Upon cell entry, activation
of the H19 gene promoter-containing plasmids and DTA expression are limited to tumor
cells, as high levels of H19 expression are only found in tumor cells. DTA disrupts
protein synthesis. Tumor-cell selective expression of this toxin leads to the selective
destruction of the tumor while sparing healthy, normal cells. H19, an oncofetal, regulatory
RNA, is overexpressed in certain cancer cells while its expression in normal cells
is minimal or absent; it plays a key role in cancer progression, angiogenesis and
metastasis.;
NCI Metathesaurus CUI : CL451873;
Origin ID : C107685;
UMLS CUI : C3827012;
Semantic type(s)
- concept_is_in_subset
