NCIt definition : An antibody against the fibroblast growth factor receptor type 2 (FGFR2), with potential
antineoplastic activity. Upon administration, aprutumab binds to and inhibits FGFR2,
which may result in the inhibition of both FGFR2 phosphorylation and FGFR2-mediated
signal transduction pathways. This results in the inhibition of cell proliferation
and the induction of cell death of FGFR2-expressing tumor cells. FGFR2, upregulated
in many tumor cell types, is a receptor tyrosine kinase, which is essential to tumor
cellular proliferation, differentiation and survival.;
Semantic type(s)