Melphalan Flufenamide

Preferred Label : Melphalan Flufenamide;

NCIt synonyms : Ethyl (2S)-2-((2S)-2-Amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanamido)-3-(4-fluorophenyl)propanoate; Melflufen; Prodrug J1; L-melphalanyl-p-L-fluorophenylalanine Ethyl Ester;

NCIt definition : A peptide-drug conjugate composed of a peptide conjugated, via an aminopeptidase-targeting linkage, to the alkylating agent melphalan, with potential antineoplastic and anti-angiogenic activities. Upon administration, the highly lipophilic melphalan flufenamide penetrates cell membranes and enters cells. In aminopeptidase-positive tumor cells, melphalan flufenamide is hydrolyzed by peptidases to release the hydrophilic alkylating agent melphalan. This results in the specific release and accumulation of melphalan in aminopeptidase-positive tumor cells. Melphalan alkylates DNA at the N7 position of guanine residues and induces DNA intra- and inter-strand cross-linkages. This results in the inhibition of DNA and RNA synthesis and the induction of apoptosis, thereby inhibiting tumor cell proliferation. Peptidases are overexpressed by certain cancer cells. The administration of melphalan flufenamide allows for enhanced efficacy and reduced toxicity compared to melphalan.;

UNII : F70C5K4786;

InChIKey : YQZNKYXGZSVEHI-VXKWHMMOSA-N;

CAS number : 380449-51-4;

Drug name : Ygalo;

Molecule name : J-1;

Codes from synonyms : 61306;

Details

Origin ID

C107680;

UMLS CUI

C1435749;

Automatic exact mappings (from CISMeF team)
- L-melphalanyl-p-L-fluorophenylalanine ethyl ester [MeSH concept]
- L-melphalanyl-p-L-fluorophenylalanine ethyl ester [MeSH Supplementary Concept]
- melphalan flufenamide [ATC Code]
Currated CISMeF NLP mapping
- Melphalan flufenamide [SMS substance]
- Melphalan flufenamide (substance) [SNOMED CT concept]
- melflufen [MeSH Supplementary Concept]
- melflufen [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- L-melphalanyl-p-L-fluorophenylalanine ethyl ester [MeSH Supplementary Concept]
- L-melphalanyl-p-L-fluorophenylalanine ethyl ester [MeSH concept]
- Melphalan flufenamide (substance) [SNOMED CT concept]
- melflufen [MeSH Supplementary Concept]
- melphalan flufenamide [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Melphalan Flufenamide Hydrochloride [NCIt concept]
is_component_of_chemotherapy_regimen
- Dexamethasone/Melphalan Flufenamide Regimen [NCIt concept]
is_free_acid_or_base_form_of
- Melphalan Flufenamide Hydrochloride [NCIt concept]

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