NCIt definition : Human ADRA2C wild-type allele is located in the vicinity of 4p16 and is approximately
2 kb in length. This allele, which encodes alpha-2C adrenergic receptor protein, plays
a role in the inhibition of G protein-coupled receptor-mediated adenylate cyclase
activity.;
NCIt note : Subjects that were homozygous for both a base pair polymorphism in the ADRB1 gene
and a deletion polymorphism in the ADRA2C gene are at higher risk for congestive heart
failure and may demonstrate a modified response to beta-blocker therapy. (OMIM);