ADRA2C wt Allele

Preferred Label : ADRA2C wt Allele;

NCIt synonyms : Adrenoceptor Alpha 2C wt Allele; Alpha2-AR-C4; ADRA2RL2; ALPHA2CAR; ADRA2L2; ADRARL2; Adrenergic, Alpha-2C-, Receptor Gene;

NCIt definition : Human ADRA2C wild-type allele is located in the vicinity of 4p16 and is approximately 2 kb in length. This allele, which encodes alpha-2C adrenergic receptor protein, plays a role in the inhibition of G protein-coupled receptor-mediated adenylate cyclase activity.;

NCIt note : Subjects that were homozygous for both a base pair polymorphism in the ADRB1 gene and a deletion polymorphism in the ADRA2C gene are at higher risk for congestive heart failure and may demonstrate a modified response to beta-blocker therapy. (OMIM);

GenBank Accession Number : AY455666;

Détails

Origin ID

C107614;

UMLS CUI

C3811649;

OMIM relation
- Alpha-2c-adrenergic receptor [OMIM Phenotype]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 4p16 [NCIt concept]
gene_is_element_in_pathway
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Motility [NCIt concept]
- Cytoskeletal Modeling [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Regulation of Cell Shape [NCIt concept]
- Regulation of Cell Size [NCIt concept]
- Signal Transduction [NCIt concept]
- Stimulation of Cell Proliferation [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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