Preferred Label : Bufalin;
NCIt synonyms : 3,14-Dihydroxy-Bufa-20,22-Dienolide; 5beta-Bufa-20,22-Dienolide, 3beta,14-Dihydroxy- (8CI); Bufa-20,22-Dienolide, 3,14-Dihydroxy-, (3beta,5beta)- (9CI); 3beta,14beta-Dihydroxy-5beta-Bufa-20,22-Dienolide; 3-Beta,14-Dihydroxy-5-Beta-Bufa-20,22-Dienolide; 5-Beta-Bufa-20,22-Dienolide, 3-Beta,14-Dihydroxy-; Bufa-20,22-Dienolide, 3,14-Dihydroxy-, (3-Beta,5-Beta)- (9CI);
NCIt definition : An active ingredient and one of the glycosides in the traditional Chinese medicine
ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the
Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity.
Although the mechanism of action of bufalin is still under investigation, this agent
is a specific Na /K -ATPase inhibitor and can induce apoptosis in cancer cell lines
through the activation of the transcription factor AP-1 via a mitogen activated protein
kinase (MAPK) pathway.;
UNII : U549S98QLW;
CAS number : 465-21-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 465-21-4
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G-SRS /a ;
Origin ID : C107555;
UMLS CUI : C0054205;
Currated CISMeF NLP mapping
- bufalin [MeSH Supplementary Concept]
- Semantic type(s)
- UMLS correspondences (same concept)
- bufalin [MeSH Supplementary Concept]
- concept_is_in_subset
