Preferred Label : CD138CAR-CD137/TCRzeta-expressing T Lymphocytes;
NCIt synonyms : CART-138 TCR zeta:CD137;
NCIt definition : T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor
(CAR) specific for syndecan-1 (CD138) (CART-138 T cells) coupled to the signaling
domain of 4-1BB (CD137), and the zeta chain of the T-cell receptor (TCRzeta), with
potential immunomodulating and antineoplastic activities. Upon transfusion, CD138CAR-
CD137/TCRzeta -expressing T lymphocytes directs the T-lymphocytes to syndecan-1-expressing
tumor cells and induces selective toxicity in those tumor cells. The 4-1BB co-stimulatory
molecule signaling domain enhances activation and signaling after recognition of syndecan-1.
Syndecan-1, a type 1 transmembrane proteoglycan and tumor associated antigen, is overexpressed
in a variety of cancer cells. It plays a key role in the regulation of cell growth,
differentiation, and adhesion, and its expression is correlated with poor prognosis.;
NCI Metathesaurus CUI : CL451751;
Origin ID : C107505;
UMLS CUI : C3831170;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
