Preferred Label : Recombinant Human Adenovirus Type 5 H101;
NCIt synonyms : rAd5 H101;
NCIt related terms : H-101;
NCIt definition : A replication selective, recombinant, E1B and partial E3 gene deleted form of human
adenovirus type 5, with potential antineoplastic activity. Upon intratumoral injection
of recombinant human adenovirus type 5, the adenovirus selectively replicates in cancer
cells while preventing viral replication in normal, healthy cells. This induces a
selective adenovirus-mediated cytotoxicity in cancer cells, which leads to cancer
cell lysis. In addition, viral spread to adjacent cells, following lysis of infected
cells, may activate the immune system to kill the infected tumor cells. The E1B protein
causes p53 inactivation, which promotes viral replication; deletion of E1B allows
for p53 activation in normal cells, which prevents viral replication in normal, healthy
cells. The mutation and subsequent inactivation of p53 in cancer cells enables the
E1B-deleted adenovirus to selectively replicate in cancer cells. Partial deletion
of E3, encoding the adenovirus death protein, enhances the safety profile of the administered
adenovirus.;
UNII : QH36X20ODG;
CAS number : 1802358-15-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1802358-15-1
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G-SRS /a ;
Drug name : Oncorine;
Molecule name : H101;
NCI Metathesaurus CUI : CL451750;
Origin ID : C107504;
UMLS CUI : C3827119;
Semantic type(s)
- concept_is_in_subset
