Preferred Label : BP-Cx1-Platinum Complex BP-C1;
NCIt definition : A combination agent composed of the benzo-poly-carbonic-acid polymer BP-Cx1 chelated
to platinum with potential antineoplastic activity. Upon intramuscular injection,
the polymer moiety of BP-Cx1-Platinum Complex BP-C1 (BP-C1) alters the permeability
of the cell membranes, which allows for increased penetration of platinum into tumor
cells. In turn, platinum binds to nucleophilic groups such as GC-rich sites in DNA
and induces intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links.
These cross-links result in apoptosis and cell growth inhibition. In addition, the
BP-Cx1 ligand is able to stimulate the innate immune system and upregulates a variety
of cytokines including interferon, tumor necrosis factor-alpha (TNF-alpha), granulocyte
macrophage-colony stimulating factor (GM-CSF), and various interleukins (ILs) such
as IL-6 and IL-25. In comparison to cisplatin and other platinum-based compounds,
treatment with BP-C1 allows for less platinum administration, which reduces platinum-associated
systemic toxicity and side effects, and enhances the safety profile while maintaining
or improving its efficacy.;
Molecule name : BP-C1;
NCI Metathesaurus CUI : CL449598;
Origin ID : C107387;
UMLS CUI : C3827148;
Semantic type(s)
- concept_is_in_subset
