Preferred Label : Topical Sirolimus;
NCIt synonyms : Rapamune Topical Formulation; NPC-12G Gel;
NCIt definition : A topical formulation containing the macrolide sirolimus (rapamycin), which is produced
by the organism Streptomyces hygroscopicus, with potential anti-proliferative activity.
Upon application of topical sirolimus, this agent migrates into the skin and is internalized
by the affected cells. In turn, sirolimus binds to the immunophilin FK binding protein-12
(FKBP-12) and forms a sirolimus:FKBP-12 complex. This complex binds to and inhibits
the activity of the serine/threonine kinase mammalian target of rapamycin (mTOR).
It also decreases the production of vascular endothelial growth factor (VEGF) and
results in the suppression of cellular proliferation.;
Molecule name : NPC-12G;
NCI Metathesaurus CUI : CL449498;
Origin ID : C107244;
UMLS CUI : C3827808;
Semantic type(s)
- concept_is_in_subset
