Preferred Label : Benzaldehyde Dimethane Sulfonate;
NCIt synonyms : BEN;
NCIt related terms : DMS-612;
NCIt definition : A dimethane sulfonate derivative and alkylating agent with a structure similar to
other alkylating agents such as chlorambucil, busulfan and melphalan, with potential
antineoplastic activity. Although the exact mechanism of action has yet to be fully
elucidated, benzaldehyde dimethane sulfonate alkylates DNA, which results in DNA double
strand breaks, inhibition of DNA replication, cell cycle arrest and cell death. In
addition, this agent is metabolized by the enzyme aldehyde dehydrogenase (ALDH) into
the active carboxylic acid metabolite benzoic acid dimethane sulfonate (BA), which
further contributes to its alkylating activity. Unlike other alkylating agents, benzaldehyde
dimethane sulfonate has demonstrated antitumor activity in renal cell carcinoma.;
UNII : 96B0BRI1JU;
InChIKey : CQVKMVQRSNNAGO-UHFFFAOYSA-N;
CAS number : 56967-08-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 56967-08-9
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G-SRS /a ;
Molecule name : NSC 281612; DMS612;
Origin ID : C107164;
UMLS CUI : C3811762;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
