Preferred Label : Oncolytic Adenovirus ICOVIR5-infected Autologous Mesenchymal Stem Cells;
NCIt definition : Bone marrow-derived autologous mesenchymal stem cells (MSCs) infected with the oncolytic,
replication-competent adenovirus ICOVIR5, with potential antineoplastic activity.
Upon infusion of the oncolytic adenovirus ICOVIR5-infected autologous MSCs, these
cells target the adenovirus to tumors. The oncolytic virus then selectively transfects
and replicates in the tumor cells causing a direct cytotoxic effect and lysis of the
tumor cells. In addition, the viral infection may stimulate an immune response against
the virally-infected tumor cells. This may lead to an inhibition of cancer cell proliferation.
ICOVIR-5, a virus derived from wild-type human adenovirus serotype 5 (Had5), has been
modified to selectively replicate in tumor cells that have a deregulated retinoblastoma/E2F
pathway.;
Drug name : Celyvir;
NCI Metathesaurus CUI : CL449421;
Origin ID : C107160;
UMLS CUI : C3828708;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
