Iproplatin - CISMeF

Preferred Label : Iproplatin;

NCIt synonyms : (OC-6-33)-dichlorodihydroxybis(2-propanamine)platinum; Diisopropylammine-trans-dihydroxymalonatoplatinum(IV); CHIP;

NCIt related terms : Platinum, dichlorodihydroxybis(2-propanamine)-, (oc-6-33)-;

NCIt definition : A synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and cell death. Although less prone to glutathione inactivation compared to cisplatin, resistance to this agent has been observed in vitro due to repair of platination damage by tumor cells. (NCI04);

UNII : 5R9F9NE9Z2;

InChIKey : AGFPKKCNKJRESC-UHFFFAOYSA-J;

CAS number : 83291-20-7; 62928-11-4;

Molecule name : JM-9;

Chemical formula : 2C3H9N.2Cl.Pt.2HO;

NSC code : 256927;

Codes from synonyms : NSC0256927;

Details

Origin ID

C1070;

UMLS CUI

C0057856;

Currated CISMeF NLP mapping
- Iproplatin [ICD-11 Extension code]
- iproplatin [MeSH concept]
- iproplatin [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Iproplatin [ICD-11 Extension code]
- iproplatin [MeSH concept]
- iproplatin [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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