Preferred Label : Protein Phosphatase 2A Inhibitor LB-100;
NCIt synonyms : PP2A Inhibitor LB-100;
NCIt related terms : LB-100;
NCIt definition : A water soluble inhibitor of the protein phosphatase 2A (PP2A), with potential chemo-
and radiotherapy enhancing activity. Upon injection, PP2A inhibitor LB-100 inhibits
the removal of phosphate groups from proteins essential for cell cycle progression.
When used with radio- or chemotherapy treatment, this agent prevents the activation
of PP2A-mediated repair mechanisms and allows for malignant cells to progress through
the cell cycle without having their damaged DNA repaired. This enhances the cytotoxic
effect of the chemotherapeutic or radiotherapeutic agent and results in tumor cell
apoptosis. PP2A, a serine/threonine phosphatase that plays a key role in the control
of cell growth and DNA damage repair.;
UNII : 0C1JUU9S0L;
CAS number : 1632032-53-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1632032-53-1
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G-SRS /a ;
Molecule name : LB-100;
Origin ID : C106430;
UMLS CUI : C3827105;
Semantic type(s)
- concept_is_in_subset
