Preferred Label : Alpha-lipoic Acid-Palladium/Vitamin/Mineral Supplement;
NCIt synonyms : Palladium Lipoic Complex; LAPd;
NCIt definition : A proprietary water- and lipid-soluble polymer-based nutritional supplement composed
of a complex mixture of alpha-lipoic acid bound to palladium (Palladium Lipoic Acid
Complex (PdLA)) and other minerals, vitamins and amino acids, including vitamins B1,
B2 and B12, formylmethionine, acetyl cysteine, and trace amounts of molybdinum, rhodium,
and ruthenium, with potential anti-oxidant and cytoprotective activities. Upon oral
administration, the alpha-lipoic acid-palladium/vitamin/mineral supplement acts as
a free radical scavenger, crosses the cell membrane and is able to transfer electrons
from fatty acids to DNA via the electron transport chain in mitochondria, which protects
against DNA damage. This could protect non-cancerous cells from the oxidative damage
caused by radiation and chemotherapy. In addition, in the hypoxic conditions found
within tumors, the excess electrons can generate free radicals within mitochondria
and could induce both cytochrome c release and apoptosis.;
Drug name : PolyMVA;
NCI Metathesaurus CUI : CL447737;
Origin ID : C106371;
UMLS CUI : C3826985;
Semantic type(s)
- concept_is_in_subset
