Preferred Label : Simmitecan Hydrochloride;
NCIt related terms : SIMMITECAN;
NCIt definition : The hydrochloride salt form of simmitecan, an ester prodrug of chimmitecan, a 9-alkyl
substituted camptothecin derivative with potential antineoplastc activity. Upon intravenous
administration, simmitecan is hydrolyzed by carboxylesterase and the activated form,
chimmitecan, is produced. Chimmitecan inhibits topoisomerase I, stabilizes covalent
topoisomerase I-DNA complexes, and inhibits the religation of topoisomerase I-mediated
single-strand DNA breaks. Futhermore, the covalent topoisomerase I-DNA complexes interfere
and block the DNA replication machinery, resulting in the production of potentially
lethal double-strand DNA breaks. This leads to an inhibition of DNA replication and
the induction of apoptosis. The modification at position 9 yields improved cytotoxicity
compared to some other camptothecin analogues.;
UNII : T4H02O147G;
CAS number : 1247847-78-4;
NCI Metathesaurus CUI : CL447735;
Origin ID : C106369;
UMLS CUI : C3828020;
Semantic type(s)
- concept_is_in_subset
