Defensins - CISMeF

Preferred Label : Defensins;

NCIt definition : Highly conserved cysteine-rich peptides that play a role in host defense, and may be produced in response to microbial products or proinflammatory cytokines. Defensins bind to microbial cell membranes and can become aggregate either to form pore-like structures or to encapsulate the microbe. These peptide aggregates lead to destabilization of the cell membrane and, subsequently, to lysis of the microbe.;

Details

Origin ID

C1063;

UMLS CUI

C0057256;

Automatic exact mappings (from CISMeF team)
- defensin beta 116 [HGNC gene]
- defensin beta 117 (pseudogene) [HGNC gene]
- defensin beta 121 [HGNC gene]
- defensin beta 124 [HGNC gene]
- defensin beta 128 [HGNC gene]
- insect defensin A [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- defensins [MeSH Descriptor]
- defensins [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- defensins [MeSH concept]
- defensins [MeSH Descriptor]

Keyword's position in hierarchy(ies) :

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