Preferred Label : Brachyury-expressing Yeast Vaccine GI-6301;
NCIt related terms : GI-6301;
NCIt definition : A cancer vaccine composed of a heat-killed, recombinant form of the yeast Saccharomyces
cerevisiae that is genetically modified to express the transcription factor brachyury
protein, with potential antineoplastic activity. Upon subcutaneous administration,
the brachyury-expressing yeast vaccine GI-6301 is recognized by dendritic cells, processed,
and presented by Class I and II MHC molecules on the dendritic cell surface. This
elicits a targeted CD4 and CD8 T-lymphocyte-mediated immune response. This process
kills brachyury-expressing tumor cells. Brachyury is overexpressed in a variety of
tumor types and plays an important role in cancer progression and metastasis.;
UNII : B0L24T8TB7;
Molecule name : GI-6301;
NCI Metathesaurus CUI : CL433965;
Origin ID : C106267;
UMLS CUI : C3827060;
Semantic type(s)
- concept_is_in_subset
- has_target
