Preferred Label : Anti-FcRH5 Antibody-drug Conjugate DFRF4539A;
NCIt synonyms : Anti-FcRH5 ADC DFRF4539A;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1)
monoclonal antibody directed against the tumor-associated antigen (TAA) Fc receptor-like
protein 5 (FcRH5; CD307; FCRL5; IRTA2; BXMAS1) and conjugated to monomethyl auristatin
E (MMAE), an auristatin derivative and a potent microtubule inhibitor, via the protease-labile
linker maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl (MC-VC-PABC), with
potential antineoplastic activity. Upon administration, the monoclonal antibody moiety
of anti-FcRH5 ADC DFRF4539A selectively binds to FcRH5 expressed on the surface of
myeloma cells. Upon internalization and proteolytic cleavage, MMAE binds to tubulin
and inhibits its polymerization, which results in G2/M phase arrest and tumor cell
apoptosis. FcRH5, an immune receptor translocation-associated protein/Fc receptor
homolog (IRTA/FCRH) family member and a B-cell lineage marker, is overexpressed on
myeloma cells.;
Molecule name : DFRF4539A; RG-7598; RG 7598;
NCI Metathesaurus CUI : CL433882;
Origin ID : C106256;
UMLS CUI : C3827135;
Semantic type(s)
- concept_is_in_subset
- has_target
