Preferred Label : Antibody-Drug Conjugate DFRF4539A;
NCIt synonyms : ADC DFRF4539A;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
a specific myeloma antigen and conjugated to monomethyl auristatin E (MMAE), an auristatin
derivative and a potent microtubule inhibitor, with potential antineoplastic activity.
Upon administration, the monoclonal antibody moiety of DFRF4539A selectively binds
to a specific protein expressed on the surface of myeloma cells. Upon internalization
and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, which
results in G2/M phase arrest and tumor cell apoptosis.;
Molecule name : DFRF4539A;
NCI Metathesaurus CUI : CL433882;
Origin ID : C106256;
UMLS CUI : C3827135;
Semantic type(s)
- concept_is_in_subset
- has_target
