Preferred Label : Olive Oil Extract/Curcumin-based Capsule;
NCIt synonyms : PhytoMed Medical Food Suppement;
NCIt definition : A capsule containing an extract of olive oil, rich in polyphenols, and curcumin, the
polyphenol derived from the plant Curcuma longa, also known as turmeric, with potential
anti-neoplastic, -angiogenic, -inflammatory, -oxidant and chemopreventive activities.
The olive oil extract/curcumin-based capsule is rich in phytonutrients, especially
polyphenols. Upon oral administration, the polyphenols, and other active ingredients
in this supplement may exert anti-inflammatory activity by decreasing the production
of inflammation mediators, such as TNF-alpha, interleukin (IL) 1-beta, IL-6, IL-10,
interferon gamma, thromboxane B2, and leukotriene B4. They also inhibit a variety
of pro-inflammatory enzymes, such as cyclooxygenase 1 (COX-1) and COX-2, block the
formation of reactive-oxygen species and neutralize free radicals. In addition, curcumin
and some other polyphenols disrupt cell signal transduction pathways involved in carcinogenesis.
Specifically, curcumin inhibits cell invasion by inhibiting matrix metalloproteinase-9
(MMP-9) expression by suppressing NF-kB and AP-1 activation.;
NCI Metathesaurus CUI : CL447409;
Origin ID : C106234;
UMLS CUI : C3828714;
Semantic type(s)
- concept_is_in_subset
