Preferred Label : Glutathione Pegylated Liposomal Doxorubicin Hydrochloride Formulation 2B3-101;
NCIt definition : A glutathione (GSH) pegylated, liposome-encapsulated preparation of the hydrochloride
salt form of the anthracycline antineoplastic antibiotic doxorubicin, with potential
anetineoplastic activity. Upon administration, the glutathione pegylated liposomal
formulation 2B3-101 specifically delivers doxorubicin into the brain. Doxorubicin
intercalates between DNA base pairs and interferes with topoisomerase II activity,
which inhibits both DNA replication and RNA synthesis, resulting in cancer cell death
and tumor regression. Doxorubicin also generates reactive oxygen species, which causes
cell membrane lipid peroxidation leading to cytotoxicity. The pegylated liposomal
delivery of doxorubicin improves drug penetration into tumors and prolongs circulation
time, thereby increasing doxorubicin's efficacy and decreasing its toxicity. Conjugation
of GSH to the PEG molecules directs the liposomes to the GSH transporters on the blood
brain barrier (BBB) and improves the delivery of doxorubicin into the brain.;
Molecule name : 2B3-101;
Origin ID : C106121;
UMLS CUI : C3827174;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
