KIR2DS1 wt Allele

Preferred Label : KIR2DS1 wt Allele;

NCIt synonyms : p50.1; CD158a; EB6ActI; XXbac-BCX195L8.7; CD158H; Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 1 wt Allele; EB6ActII;

NCIt definition : Human KIR2DS1 wild-type allele is located in the vicinity of 19q13.4 and is approximately 14 kb in length. This allele, which encodes killer cell immunoglobulin-like receptor 2DS1 protein, is involved in the modulation of NK cell function.;

NCIt note : Members of the KIR gene family are polymorphic and highly homologous. These genes are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). (EntrezGene); Expression of the KIR2DS1 gene by donor cells may be associated with reduced risk of relapse of acute myelogenous leukemia in patients treated with blood stem cell transplants. (NCI Cancer Bulletin. Sept 4, 2012.);

GenBank Accession Number : NM_014512;

Details

Origin ID

C106093;

UMLS CUI

C3811111;

Automatic exact mappings (from CISMeF team)
- Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 [OMIM gene]
- Killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 [OMIM gene]
- receptors, kir2dl1 [MeSH Descriptor]
OMIM relation
- Killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 19q13.4 [NCIt concept]
gene_is_element_in_pathway
- Antigen Processing and Presentation Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
gene_plays_role_in_process
- Immune Response Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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