NCIt related terms : ChIP-Seq (chromatin ImmunoPrecipitation);
NCIt definition : A molecular genetic technique that combines chromatin immunoprecipitation (ChIP) with
massively parallel DNA sequencing to map the binding sites of DNA-associated proteins
in a sample of cells. First, crosslinked protein-DNA complexes are isolated using
ChIP. Next, the crosslinks are broken, the proteins are removed and the purified DNA
is modified with adaptor oligonucleotides to facilitate massively parallel DNA sequencing.
Following sequencing, the DNA sequences that are obtained can be mapped to their genomic
locations.;