Preferred Label : [18F]L-FMAC;
NCIt synonyms : 2'-Deoxy-2'-18F-fluoro-5-methyl-beta-L-arabinofuranosylcytosine; L-fluorine F 18-FMAC;
NCIt related terms : L-FMAC F-18;
NCIt definition : A radioconjugate composed of 2'-deoxy-2'-18F-fluoro-5-methyl-beta-L-arabinofuranosylcytosine
([18F]L-FMAC), a L-deoxycytidine analog and high-affinity substrate for deoxycytidine
kinase (DCK), labeled with fluorine F 18, with potential diagnostic activity during
positron emission tomography (PET) imaging. Upon administration, [18F]L-FMAC is preferentially
taken up by and accumulated in cells with high DCK levels, including tumor cells with
dysregulated nucleoside metabolism. After phosphorylation by DCK, the 18F moiety can
be visualized by PET imaging. As many nucleoside analog prodrugs are chemotherapeutic
agents that require DCK for their phosphorylation and activation, [18F]L-FMAC can
potentially be used as a marker to measure DCK activity and to predict the chemotherapeutic
efficacy of DCK-dependent prodrugs. DCK, a rate-limiting enzyme in the deoxyribonucleoside
salvage pathway for DNA synthesis, is overexpressed in certain solid tumors, lymphoid
and myeloid malignancies and certain immune cells, such as proliferating T-lymphocytes.
The L-enantiomer is less susceptible to deamination by cytidine deaminase (CDA) than
the D-enantiomer and increases the stability of this radioconjugate.;
UNII : 1550OGY7TD;
InChIKey : QZZJZXAWLQYJFK-HMQZJZAASA-N;
CAS number : 1134848-13-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1134848-13-7
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G-SRS /a ;
NCI Metathesaurus CUI : CL447178;
Origin ID : C105850;
UMLS CUI : C3827304;
Semantic type(s)
- concept_is_in_subset
- has_target
