Preferred Label : Ad-hCMV-TK;
NCIt definition : A human serotype 5, replication-defective, first generation adenoviral vector, with
the viral E1a and E3 protein encoding regions deleted, which is engineered to express
the herpes simplex virus thymidine kinase (HSV-tk) gene under the transcriptional
control of the CMV promoter. This agent, when administered in conjunction with a synthetic
acyclic guanosine analogue, possesses potential antineoplastic activity. Upon administration
into the peritumoral region after tumor resection, adenoviral vector encoding HSV
thymidine kinase is transduced into tumor cells, and HSV-tk is expressed. Tumor cells
expressing HSV-tk are sensitive to synthetic acyclic guanosine analogues. Subsequent
administration of a synthetic acyclic guanosine analogue, such as valacyclovir (VCV)
or ganciclovir (GCV), kills the tumor cells expressing HSV-tk. The release of tumor-associated
antigens (TAA) by dying tumor cells may then stimulate an antitumor cytotoxic T lymphocyte
(CTL) response, directed aganst any remaining tumor cells.;
NCI Metathesaurus CUI : CL447163;
Origin ID : C105811;
UMLS CUI : C3831602;
Semantic type(s)
- concept_is_in_subset
