Preferred Label : AdGMCAIX-transduced Autologous Dendritic Cells;
NCIt synonyms : DC-AdGMCAIX; DCs expressing CMCA9 Gene;
NCIt definition : Autologous dendritic cells (DCs) transduced with a recombinant, replication-defective
adenoviral vector expressing the fusion gene granulocyte-macrophage colony-stimulating
factor (GM-CSF) and carbonic anhydrase IX (CA-IX or CA9) (GMCA-9), with potential
immunomodulating activity. The autologous DCs are transduced ex vivo and express the
GMCA-9 fusion protein on the cell surface. Upon intradermal administration of the
AdGMCAIX-transduced autologous DCs back into the patient, the DCs activate the immune
system to both mount a cytotoxic T lymphocyte-mediated response against tumor cells
positive for the CA9 antigen, and generate memory T cells. This may result in decreased
tumor growth. CA9, also known as G250, is a renal cell carcinoma (RCC)-associated
antigen and a member of the carbonic anhydrase family that contains a human leukocyte
antigen (HLA)-A2.1-restricted epitope; it is found in a majority of renal cell carcinomas
while absent in most normal tissues. The cytokine GM-CSF enhances the immunogenicity
of CA9-based DC vaccines.;
NCI Metathesaurus CUI : CL447161;
Origin ID : C105809;
UMLS CUI : C3827013;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
