Preferred Label : Indium In 111 Pertuzumab;
NCIt synonyms : 111In-pertuzumab;
NCIt definition : A radioimmunoconjugate composed of a humanized recombinant monoclonal antibody directed
against the extracellular dimerization domain of the tyrosine kinase receptor human
epidermal growth factor-2 (HER-2) and linked to the gamma-emitting radioisotope indium
In 111, with potential use in radioimaging. Upon administration, indium In 111 pertuzumab
binds to HER-2. After binding and internalization into HER-2-expressing tumor cells,
radioactive In 111 facilitates the detection of HER-2-expressing tumor cells using
single photon emission computed tomography (SPECT). This may predict or evaluate the
tumor's response to certain HER-2-targeting chemotherapeutics.;
NCI Metathesaurus CUI : CL447160;
Origin ID : C105808;
UMLS CUI : C3829542;
Semantic type(s)
- concept_is_in_subset
