Preferred Label : Liposome-encapsulated miR-34 Mimic MRX34;
NCIt definition : A liposomal formulation containing a nucleotide that mimics the human tumor suppressor
microRNA (miRNA) miR-34, with potential antineoplastic activity. Upon administration,
liposome-encapsulated MRX34 mimics miR-34 by inhibiting the expression of a variety
of oncogenes including MYC, MET, BCL2, and beta-catenin. This induces cell cycle arrest,
senescence and apoptosis in susceptible tumor cells. miR-34 is downregulated in most
solid and hematologic malignancies and regulates the expression of a variety of genes.
This miRNA plays an important role in the inhibition of cancer cell stemness, metastasis
and cancer cell survival.;
Molecule name : MRX34;
NCI Metathesaurus CUI : CL447293;
Origin ID : C105802;
UMLS CUI : C3813584;
Semantic type(s)
- concept_is_in_subset
