Preferred Label : ALK Inhibitor RO5424802;
Obsolete resource : true;
NCIt definition : An orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma
kinase (ALK) with antineoplastic activity. Upon administration, ALK inhibitor RO5424802
binds to and inhibits ALK kinase, which leads to a disruption of ALK-mediated signaling
and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells. ALK belongs
to the insulin receptor superfamily and plays an important role in nervous system
development. ALK dysregulation and gene rearrangements are associated with a series
of tumors. Additionally, ALK mutations are associated with acquired resistance to
small molecule tyrosine kinase inhibitors.;
NCIt note : See 'Alectinib(C101790)';
Concept status : Retired_Concept;
Molecule name : RO5424802;
NCI Metathesaurus CUI : CL446452;
Origin ID : C105615;
UMLS CUI : C3642266;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
