Preferred Label : Depatuxizumab Mafodotin;
NCIt definition : An antibody-drug conjugate (ADC) consisting of depatuxizumab, a humanized monoclonal
antibody directed against human epidermal growth factor receptor (EGFR), conjugated
to the auristatin derivative monomethyl auristatin F (MMAF), with potential antineoplastic
activity. Upon administration of depatuxizumab mafodotin, depatuxizumab targets and
binds to EGFR expressed on tumor cell surfaces. Upon internalization, the MMAF moiety
is released, binds to tubulin and inhibits its polymerization, which may result in
G2/M phase arrest, tumor cell apoptosis and inhibition of cellular proliferation in
tumor cells that overexpress EGFR. EGFR, a receptor tyrosine kinase mutated in many
tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.;
UNII : F3R7A4P04N;
CAS number : 1585973-65-4;
Molecule name : ABT-414;
NCI Metathesaurus CUI : CL446449;
Origin ID : C105612;
UMLS CUI : C4477221;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- ABT-414 [MeSH Supplementary Concept]
- Semantic type(s)
- UMLS correspondences (same concept)
- ABT-414 [MeSH Supplementary Concept]
- concept_is_in_subset
- has_target
