Preferred Label : Monocarboxylate Transporter 1 Inhibitor AZD3965;
NCIt synonyms : MCT1 Inhibitor AZD3965;
NCIt related terms : AZD-3965;
NCIt definition : An orally available inhibitor of monocarboxylate transporter 1 (MCT1), with potential
antineoplastic activity. Upon oral administration, MCT1 inhibitor AZD3965 binds to
MCT1 and prevents the transport of lactate into and out of the cell. This leads to
an accumulation of lactate, intracellular acidification, and eventually cancer cell
death. MCT1, a protein overexpressed on tumor cells, is responsible for the transport
of monocarboxylates across the cell membrane and plays a key role in cell metabolism.;
UNII : 39OM5Y4K2F;
CAS number : 1448671-31-5;
Molecule name : AZD3965;
Origin ID : C105399;
UMLS CUI : C3642150;
Semantic type(s)
- UMLS correspondences (same concept)
- AZD3965 [MeSH Supplementary Concept]
- concept_is_in_subset
