Preferred Label : Rivogenlecleucel;
NCIt definition : Allogeneic, T-lymphocytes with potential immune reconstitution activity. Donor T-lymphocytes
are transduced with a retroviral vector (BPZ-1001) encoding the inducible suicide
gene caspase 9 (iCasp9) and linked to a drug binding domain. Donor T-cell therapy
may help control transplant-related infections following allogeneic hematopoietic
stem cell transplantation. However, the addition of donor T-cells can lead to graft-versus-host
disease (GVHD). In the event that GVHD begins to develop, the chemical homodimerizer
AP1903 can be administered, which binds to the drug binding domain and induces caspase
9 expression. This activates apoptosis in the T-cells causing GVHD.;
UNII : E6349B696W;
Molecule name : BPX-501;
NCI Metathesaurus CUI : CL446320;
Origin ID : C105395;
UMLS CUI : C3642149;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
