Preferred Label : Phenethyl Isothiocyanate-containing Watercress Juice;
NCIt synonyms : PEITC-containing Watercress Juice;
NCIt definition : A juice extracted from watercress containing high amounts of phenethyl isothiocyanate
(PEITC), with potential chemopreventive and antitumor activities. Although the mechanism(s)
of action through which PEITC exerts its effect(s) has yet to be fully elucidated,
PEITC is able to induce apoptosis in tumor cells through the induction of reactive
oxygen species (ROS). Additionally, PEITC is able to modulate extracellular signal-regulated
kinases (ERK), c-Jun N-terminal kinase (JNK) and mitogen-activated protein kinase
(MAPK) signal transduction pathways, activating the expression of stress-responsive
genes and eventually inducing apoptosis. PEITC also inhibits the expression of genes
involved in tumor progression such as HIF, STAT-3, HER2, BCL-XL, and XIAP and induces
the expression of genes involved in tumor suppression such as p53, ATF-2, and p57.
Furthermore, this agent has been shown to reactivate the gene expression of certain
detoxification enzymes.;
NCI Metathesaurus CUI : CL446318;
Origin ID : C105392;
UMLS CUI : C3642148;
Semantic type(s)
- concept_is_in_subset
