" /> Savolitinib - CISMeF





Preferred Label : Savolitinib;

NCIt synonyms : Volitinib;

NCIt definition : An orally bioavailable inhibitor of the c-Met receptor tyrosine kinase with potential antineoplastic activity. Savolitinib selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. This may result in cell growth inhibition in tumors that overexpress the c-Met protein. C-Met encodes the hepatocyte growth factor receptor tyrosine kinase and plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis; this protein is overexpressed or mutated in a variety of cancers.;

UNII : 2A2DA6857R;

InChIKey : XYDNMOZJKOGZLS-NSHDSACASA-N;

CAS number : 1313725-88-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1313725-88-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : HMPL-504; AZD6094; AZD 6094;

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Keyword's position in hierarchy(ies) : arborescence

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15/05/2024


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