" /> Savolitinib - CISMeF





Preferred Label : Savolitinib;

NCIt synonyms : Volitinib;

NCIt definition : An orally bioavailable inhibitor of the c-Met receptor tyrosine kinase with potential antineoplastic activity. Savolitinib selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. This may result in cell growth inhibition in tumors that overexpress the c-Met protein. C-Met encodes the hepatocyte growth factor receptor tyrosine kinase and plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis; this protein is overexpressed or mutated in a variety of cancers.;

UNII : 2A2DA6857R;

InChIKey : XYDNMOZJKOGZLS-NSHDSACASA-N;

CAS number : 1313725-88-0;

Molecule name : HMPL-504; AZD6094; AZD 6094;

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08/05/2025


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