Septin-4 - CISMeF

Preferred Label : Septin-4;

NCIt synonyms : CE5B3 Beta; Apoptosis-Related Protein In The TGF-Beta Signaling Pathway; Brain Protein H5; Bradeion Beta; ARTS; SEPT4; hCDCREL-2; Peanut-Like Protein 2; Cerebral Protein 7; Cell Division Control-Related Protein 2; Septin-M; SEPTIN4;

NCIt definition : Septin-4 (478 aa, 55 kDa) is encoded by the human SEPTIN4 gene. This protein is involved in both cytoskeletal structure and GTP hydrolysis.;

NCIt note : There are at least 6 isoforms of septin-4 produced by alternative splicing. One isoform, apoptosis-related protein in the TGF-beta signaling pathway (ARTS), is localized in mitochondria and is required for the induction of cell death mediated by TGF-beta and by other apoptotic signals. (UniProt);

Details

Origin ID

C104505;

UMLS CUI

C3538896;

Automatic exact mappings (from CISMeF team)
- Arts [UNESCO concept]
- Arts syndrome [OMIM Phenotype]
- Arts syndrome [DO Concept]
- Contact with health services for assisted reproductive technology [ICD-11 Subcategory]
- Septin 4 [OMIM gene]
- art [MeSH Descriptor]
- septin 4 [HGNC gene]
False automatic mappings
- reproductive techniques, assisted [MeSH Descriptor]
OMIM relation
- Septin 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- SEPTIN4 Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoskeleton [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Promoter [NCIt concept]
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Cytokinesis [NCIt concept]
- GTP Binding [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]

Keyword's position in hierarchy(ies) :

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