Preferred Label : Autologous GM-CSF-secreting Lethally Irradiated Leukemia Cell Vaccine;
NCIt synonyms : Autologous GVAX Leukemia Vaccine;
NCIt definition : An autologous cancer vaccine composed of lethally irradiated leukemia cells that are
genetically modified to secrete the immunostimulatory cytokine granulocyte-macrophage
colony-stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic
activities. Upon intradermal injection, the autologous GM-CSF-secreting lethally irradiated
leukemia cell vaccine secretes GM-CSF. In turn, GM-CSF may stimulate the immune system
to attack tumor cells by enhancing the activation of dendritic cells (DCs) and promoting
antigen presentation to both B- and T-lymphocytes. In addition, GM-CSF promotes antibody-dependent
cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated
killer cell function.;
NCI Metathesaurus CUI : CL445684;
Origin ID : C104419;
UMLS CUI : C3641795;
Semantic type(s)
- concept_is_in_subset
