Preferred Label : Gene-Modified HIV-Protected Hematopoietic Stem Cells;
NCIt definition : Autologous hematopoietic stem cells (HSCs) genetically modified to be resistant to
infection by human immunodeficiency virus (HIV). Allogeneic human autologous HSCs
are isolated and transduced ex vivo with three different anti-HIV genes. Upon infusion
into the HIV-infected lymphoma patient, the gene-modified HIV-protected HSCs are resistant
to HIV entry and replication thereby preventing HIV infection in these proliferating
stem cells and any differentiated cells that they give rise to. This results in the
formation of immune cells resistant to HIV which also may be able to destroy HIV-infected
cells.;
NCI Metathesaurus CUI : CL445682;
Origin ID : C104415;
UMLS CUI : C3641794;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
