Preferred Label : Geranylgeranyltransferase I Inhibitor;
NCIt synonyms : GGTI-I; GGTase-I Inhibitor;
NCIt definition : A substance that inhibits protein geranylgeranyltransferase type 1 (GGTase-I), with
potential antineoplastic activity. GGTase-I is involved in the posttranslational modification
of a number of oncogenic GTPases, including K-Ras, N-Ras, RhoA, RhoC, Cdc42, RalA,
RalB and Rac1. Inhibition of the prenylation of these oncogenic proteins inhibits
both their oncogenic activity and membrane localization. This may result in cell cycle
arrest and apoptosis. Protein geranylgeranylation, catayzed by GGTase-I, plays a critical
role in malignant transformation and cancer cell proliferation, migration and invasion.;
NCI Metathesaurus CUI : CL445681;
Origin ID : C104414;
UMLS CUI : C3641793;
Semantic type(s)
- concept_is_in_subset
- has_target
