Preferred Label : Roneparstat;
NCIt synonyms : 100NA,RO-H;
NCIt definition : An N-acetylated, glycol-split form of heparin that is devoid of anticoagulant activity
and is an inhibitor of heparanase with antineoplastic and antiangiogenic activities.
Upon subcutaneous administration, roneparstat inhibits the activity of heparanase.
This prevents the heparanase-mediated cleavage of heparan sulfate (HS) proteoglycans
on cell surfaces and within the extracellular matrix. In addition, this agent prevents
the heparanase-induced production of a number of angiogenic growth factors, including
matrix metalloproteinase-9, hepatocyte growth factor and vascular endothelial growth
factor. Altogether, this leads to an inhibition of both tumor cell growth and angiogenesis.
Heparanase, an enzyme that is responsible for the proteolytic cleavage of proteoglycans,
is upregulated in a variety of tumor cell types and promotes tumor cell growth; it
plays a key role in tumor cell invasion, metastasis and angiogenesis.;
UNII : 1J0593208B;
CAS number : 1407492-04-9;
Molecule name : SST0001;
Origin ID : C104412;
UMLS CUI : C5235366;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
