Preferred Label : Itraconazole Dispersion In Polymer Matrix;
NCIt synonyms : SUBA-Itraconazole;
NCIt definition : A proprietary oral formulation composed of the poorly soluble, synthetic triazole
agent, itraconazole, dispersed in a polymer matrix, with antifungal and potential
anti-angiogenic activities. Upon oral administration, itraconazole inhibits the enzyme
cytochrome P450 lanosterol 14 alpha-demethylase, resulting in a decrease in fungal
ergosterol synthesis. Although the exact mechanism through which itraconazole inhibits
angiogenesis has yet to be fully elucidated, this agent appears to inhibit the Hedgehog
(Hh) signaling pathway, cholesterol synthesis and mammalian target of rapamycin (mTOR)
signaling in endothelial cells. This agent may also prevent the activation of and
signaling by various angiogenic growth factors. By decreasing the tumor vasculature
and nutrient supply, itraconazole ultimately inhibits tumor cell growth. The solid
dispersion of itraconazole in the polymer matrix enhances dissolution of itraconazole
in the gastrointestinal tract and increases its bioavailability; this allows for the
administration of a much lower dose compared to itraconazole alone.;
NCI Metathesaurus CUI : CL439067;
Origin ID : C104048;
UMLS CUI : C3641717;
Semantic type(s)
- concept_is_in_subset
